• dangling_cat@piefed.blahaj.zone
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    5 hours ago

    I saw a study somewhere about this, something like it will create a larger spike at first but a shorter halflife . Since it’s a daily pill, it won’t make much difference. Maybe protect your liver more.

    • Hildegard (she/her)@lemmy.blahaj.zone
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      4 hours ago

      That is accurate, but it also has higher bioavailability when taken sublingually so you get more estrogen for the same number of pills. Its easier on the liver that way, but it requires you to take it multiple times per day.

      I take mine every 12 hours now. I did every 8 hours when I was on a dose that was divisible by three. The spikes haven’t been an issue for me. Biology works in averages.

    • queermunist she/her@lemmy.ml
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      5 hours ago

      Yeah, it’s for liver health, but also that rollercoaster effect can be mitigated by taking a smaller sublingual dose multiple times a day.

    • TessaRekt@lemmy.dbzer0.com
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      4 hours ago

      Yeah it doesn’t actually matter which way you take it, just that it is consistent. Won’t actually help your liver more either way since the stuff that can harm your liver is actually one of metabolites of the medication made when your liver turns it into usable estrogen not the medication itself.

      People worried about their liver should be doing patches or injections if possible.